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Adrenal insufficiency is caused by destruction of the adrenal cortex, deficient pituitary ACTH secretion, or deficient hypothalamic secretion of corticotropin releasing hormone. The prominent symptoms are weakness, fatigue, weight loss, and gastrointestinal complaints, but these symptoms are common to many other diseases. Thus, the diagnosis of adrenal insufficiency needs the exception of other diseases. Primary adernal insufficiency comes from autoimmune disease, granulomatous disease, metastatic malignancies such as lung and breast carcinoma, hemorrhagic infarction associated with anticoagulant therapy or meningococcemia, and rare hereditary diseases. In this paper, we present a case of lung cancer with adrenal metastasis which causes adrenal insufficiency. The patient was treated with chemotherapy and steroid replacement therapy successfully.
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